Dr. Huang’s Research

While serving the people as a full-time cardiologist, Dr. Huang’s unstoppable passion in cardiovascular research to save lives never fades. He is a distinguished researcher who has authored and co-authored 49 peer-reviewed articles in highly respected medical journals such as the Journal of Clinical Investigation and New England Journal of Medicine. He has also received various research grants and academic achievement awards from the American Heart Association and the National Institute of Health (NIH). 


image papersIn 1996, Dr. Huang pioneered in the discovery of Intrinsic Cardiac Adrenergic Cells. Through his research, he discovered that these cells are critical to prolong a person’s life after a heart attack. In 2009, Dr. Huang discovered a novel combination of drugs that can reduce heart muscle damage after a heart attack (US patent awarded). Since then, his research term has demonstrated excellent clinical safety profile of this novel therapy and published their results in the European Journal of Clinical Pharmacology. Currently, Dr. Huang and his international collaborators are recruiting patients for a phase II clinical efficacy trial in patients with acute heart attack.

Selected from 49 peer reviewed publications (click article to print)

1. Huang MH, Smith FM, Armour JA. Amino acids modify the activity of canine intrinsic cardiac neurons involved in cardiac regulation. Am J Physiol. 264: H1275-H1282, 1993.

2. Horackova M, Huang MH, Armour JA, Hopkins DA, Mapplebeck C. Co-cultures of adult ventricular myocytes with stellate ganglia or intrinsic cardiac neurons from guinea pig: spontaneous activity and pharmacological properties. Cardiovasc Res. 27:1101-1108, 1993.

3. Huang MH, Smith FM, Armour JA. Modulation of in situ canine intrinsic cardiac neuronal activity by nicotinic, muscarinic and β-adrenergic agonists. Am J Physiol. 265:R659-R669, 1993.

4. Huang MH, Sylvèn C, Pelleg A, Smith FM, Armour JA. Modulation of canine in situ intrinsic cardiac neurons by local application of adenosine and ATP. Am J Physiol. 265: R914-R922, 1993.

5. Huang MH, Wolf S, Armour JA. Cardiac arrhythmias induced by chemically modified intrinsic cardiac neurons. Cardiovasc Res. 28:636-642, 1994.

6. Horackova M, Huang MH, Armour JA. Purinergic modulation of adult guinea pig cardiomyocytes in long-term cultures and cocultures with extracardiac or intracardiac neurons. Cardiovasc Res. 28:673-679, 1994.

7. Adamson PB, Huang MH, Vanoli E, Schwartz PJ, Foreman RD, Hull SS. Unexpected interaction between beta-adrenergic blocker and heart rate variability before and after myocardial infarction: a longitudinal study in dogs at high and low risk for sudden death. Circulation. 90:976-982, 1994.

8. Armour JA, Huang MH, Pelleg A, Sylvèn C. Activity generated by in situ canine nodose ganglion neurons connected to cardiac mechanoreceptors and/or chemoreceptors. Cardiovasc Res. 28:1218-1225, 1994.

9. Huang MH, Sylvén C, Horackova M, Armour JA. Ventricular sensory neurons in canine dorsal root ganglia: effects of adenosine and substance P. Am J Physiol. 269:R318-R324, 1995.

10. Huang MH, Armour JA, Wolf S. Shortening of QT interval of the ECG is associated primarily with increased ventricular contractility rather than heart rate. Integ Physiol Behav Sci. 30:5-11, 1995.

11. Huang MH, Horackova M, Negoescu RM, Wolf S, Armour JA. Polysensory response characteristics of dorsal root ganglion neurons that may serve sensory functions during myocardial ischemia. Cardiovasc Res. 32:503-515, 1996.

12. Huang MH, Friend DS, Sunday ME, Singh K, Haley K, Austen KF, Kelly RA, Smith TW. An intrinsic adrenergic system in mammalian heart (with cover figure & editorial comment). J Clin Invest. 98:1298-1303, 1996.

13. Huang MH, Knight PR III, Izzo JL. Ca2+-dependent Ca2+ mobilization involved in CGRP-mediated positive inotropic effect in ventricular myocytes. Am J Physiol. 276:R259-R264, 1999.

14. Huang MH, Ewy GA. Sympathetic reinnervation of transplanted heart. N Engl J Med. (letter). 345:1914-1915, 2001.

15. Huang MH, Hu H, Plata E, Yahia AM, Goldfarb A, Izzo JL. Exceptional survivor of a patient with large ventricular septal defect, bi-directional shunt, and severe pulmonary valve stenosis (case report). J Am Soc Echocardiogr. 15:665-667, 2002.

16. Huang MH, Xavier L, Walsh K, Morrison DA. A coronary-left ventricular fistula associated with myocardial ischemia (case report). Clin Cardiol. 25:441, 2002.

17. Huang MH, Ewy GA. Cardiac syndrome X. N Engl J Med. (letter). 347:1377, 2002.

18. Fernandez SF, Huang MH, Davison B, Knight PR, Izzo JL Jr. Modulation of angiotensin II responses in sympathetic neurons by cytosolic calcium. Hypertension. 41:56-63, 2003.

19. Huang MH, Roeske WR, Hu H, Indik JH, Marcus FI. Postural position and neurocardiogenic syncope in late pregnancy. Am J Cardiol. 92:1252-1253, 2003.

20. Huang MH, Marcus FI. Idiopathic Brugada-type electrocardiographic pattern in an octogenarian (case report). J Electrocardio. 37:109-111, 2004.

21. Huang MH, Bahl JJ, Wu Y, Larson DL, Hu FL, Ewy GA. Neuroendocrine properties of intrinsic cardiac adrenergic cells in fetal rat heart. Am J Physiol Heart Circ. Physiol. 288: H497-H503, 2005.

22. Fernandez SF, Huang MH, Davison B, Knight PR III, Izzo JL Jr. Mechanisms of angiotensin II-mediated decreases in cytosolic calcium in Ca2+-loaded sympathetic neurons. Hypertension. 45:276-282, 2005.

23. Huang MH, Wang HQ, Roeske WR, Birnbaum Y, Wu Y, Yang NP, McAdoo DJ, Hughes MG, Lick SD, Boor PJ, Lui CY, Uretsky BF. Mediating d-opioid-initiated heart protection via the β2-adrenergic receptor: role of the intrinsic cardiac adrenergic cell. Am J Physiol Heart Circ Physiol. 293:H376-H384, 2007.

24. Huang MH, Nguyen V, Wu Y, Rastogi S, Birnbaum Y, Lui CY, Ware DL, Wang H, Chauhan M, Garg N, Poh KK, Lei Y, Omar AR, Tan HC, Uretsky BF, Fujise K. Reducing ischemia/reperfusion injury through d-opioid-regulated intrinsic cardiac adrenergic cells: adrenopeptidergic co-signaling. Cardiovasc Res. 84: 452-460, 2009.

25. Gupta S, Bhatia V, Wen J, Wu Y, Huang MH, Garg N. Trypanosoma cruzi infection disturbs mitochondrial Δym and ROS production rate in cardiomyocytes. Free Radic Biol Med. 47:1414-1421, 2009.

26. Huang MH, Lui CY, Abusaid GH, Poh KK, Barbagelata AN, Uretsky BF, Fujise K. Cardiac calcitonin gene-related peptide and left ventricular hypertrophy in cardiac allograft. J Heart Lung Transplantation. 29:487-488, 2010.

27. Wu Y, Yin X, Wijaya C, Huang MH, McConnell BK. Acute myocardial infarction in rats. JoVE 48: 2011. http://www.jove.com/index/details.stp?ID=2464.doi:10.3791/2464.

28. Huang MH, Wu Y, Nguyen V, Rastogi S, McConnell BK, Wijaya C, Poh KK, Tan HC, Uretsky BF, Fujise K. Heart Protection by combination therapy with milrinone and esmolol at early reperfusion during acute myocardial infarction. Cardiovasc Drugs Therapy. 25:223-232, 2011.

29. Nguyen VT, Wu Y, Guillory AN, McConnell BK, Fujise K, Huang MH. d-opioid augments cardiac contraction through β-adrenergic and CGRP-receptor co-signaling. Peptides. 33:77-82, 2012.

30. Poh KK, Xu X, Sia W, Chan MY, Low AF, Chan KH, Lee CH, Teo SG, Tang LQ, Tan HC, Lui CY, Nguyen V, Fujise K, Huang MH. Safety of combination therapy with milrinone and esmolol in heart protection during percutaneous coronary intervention in acute myocardial infarction. Euro J Clin Pharmacol 70:527-530, 2014.

Accredited Labs

       image accredit6 image accredit5   

Gulf Coast Heart Clinics are equipped with advanced technologies and equipments. The Echo & Nuclear Cardiology Laboratories are accredited by the Intersocietal Accreditation Commission (ICA)

League City Location

Located at 501 Gulf Freeway South, Suite 106, League City, TX 77573.

Phone: (281) 534-8600

CLICK FOR MAP   

Houston Location

Located at 9600 Bellaire Blvd, Suite 202, Houston, TX 77036.

Phone: (713) 771-6969  Fax: (713) 270-6969 

CLICK FOR MAP